Abstracts für Posterpräsentationen (in englischer Sprache) bitte per Email an office@brainplatform.net. Folgendes Format ist zwingend notwendig, da angestrebt wird, die Abstracts in Pharmacopsychiatry zu publizieren:

Sprache: Englisch
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Deadline für Einreichung von Abstracts: 15. Februar 2018


Beispielabstract (von TDM Symposium 2016): 

TDM of psychotropic drugs in body fluids

Braun D., Stegmann B., Haen E. 

Klinische Pharmakologie am Lehrstuhl für Psychiatrie und Psychotherapie und am Lehrstuhl für Pharmakologie und Toxikologie, University of Regensburg, Germany

In therapeutic drug monitoring (TDM) serum or plasma is an often utilized biological matrix. Investigations on less invasive body fluids like saliva or urine are an important issue, as there are practical problems with blood testing especially with children.
If saliva would be used in TDM, the saliva to plasma concentration ratio should be constant over a wide plasma concentration range. This correlation was shown for some anticonvulsant drugs like phenytoin and carbamazepine. Other active substances like the psychostimulants methylphenidate and dexamphetamine show highly variable ratios of saliva to plasma concentration, depending on the salivary pH and the plasma protein binding of the drug. In that case saliva samples are useful for qualitative detection of drugs and for assuring compliance, but not for optimizing an existing pharmacotherapy by TDM.
Urine is suitable for controlling compliance and for testing drug abuse, as many drugs are detectable in it. However quantification of drugs in urine is problematic. Many factors like the hydration status of the body or the urinary pH influence the concentrations.
Another interesting body fluid for quantification of active substances is cerebrospinal fluid (CSF). Its normally low protein content simplifies sample preparation for HPLC. Furthermore CSF may reveal the presence of a psychotropic drug at the site of action. For example the neuroleptic drug olanzapine shows a clear-cut correlation between concentrations in serum and in CSF, indicating that serum concentrations of olanzapine reflect those in CSF.
In most instances serum or plasma is the most appropriate body fluid for TDM.


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